Article
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.
Cell - 30 Jul 1993
Rebay I, Fehon R G, Artavanis-Tsakonas S
Abstract excerpt
The Notch gene of Drosophila plays an important role in cell fate specification throughout development. To investigate the functions of specific structural domains of the Notch protein in vivo, a series of deletion mutants have been ectopically expressed under the hsp70 heat shock promoter. Two c...
Topics
- Animals
- Ankyrins
- Cell Compartmentation
- Cell Cycle Proteins
- DNA Mutational Analysis
- Drosophila
- Drosophila Proteins
- Fungal Proteins
- Heat-Shock Proteins
- Insect Hormones
- Membrane Proteins
- Mutation
- Phenotype
- Promoter Regions, Genetic
- Receptors, Notch
- Recombinant Fusion Proteins
- Schizosaccharomyces pombe Proteins
- Sequence Deletion