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Article

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

Cell - 30 Jul 1993

Rebay I, Fehon R G, Artavanis-Tsakonas S

Abstract excerpt

The Notch gene of Drosophila plays an important role in cell fate specification throughout development. To investigate the functions of specific structural domains of the Notch protein in vivo, a series of deletion mutants have been ectopically expressed under the hsp70 heat shock promoter. Two classes of dominant phenotypes are observed, one suggestive of Notch loss-of-function mutations and the other of Notch...

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PMID: 8343959
DOI: 10.1016/0092-8674(93)90423-n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.PMID 8343959Read ↗

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[Role of Cre-loxP-mediated conditional gene targeting in understanding the function of Notch receptors].Semantic proximity Read ↗

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