Article
Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2001
Hsu H C, Shultz L D, Su X, Shi J, Yang P A, Relyea M J, Zhang H G, Mountz J D
Abstract excerpt
To determine the role of Src homology protein tyrosine phosphatase (SHP-1) in the ionizing radiation-induced stress response, we analyzed the apoptotic response and cell cycle function in irradiated spleen cells of motheaten (me/me) mice. The defect in me/me mice has been attributed to mutations of the HCPH: gene, which encodes SHP-1. Homozygotes develop severe systemic autoimmune and inflammatory disease,...
Topics
- Animals
- Apoptosis
- Cell Cycle
- Cell Death
- Cell Line
- Gamma Rays
- Hybridomas
- Immunity, Innate
- Intracellular Membranes
- Intracellular Signaling Peptides and Proteins