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Article

Pausing of the restriction endonuclease EcoRI during linear diffusion on DNA.

Biochemistry - 30 Aug 1994

Jeltsch A, Alves J, Wolfes H, Maass G, Pingoud A

Abstract excerpt

Linear diffusion is a mechanism to accelerate association rates beyond their three-dimensional diffusional limit. It is employed by the restriction endonuclease EcoRI as well as many other proteins interacting with specific DNA sequences to locate their target sites on the macromolecular substrate. In order to investigate biochemical and biophysical details of the linear diffusion process, we have developed a...

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PMID: 8068662
DOI: 10.1021/bi00200a001

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