Article
Pausing of the restriction endonuclease EcoRI during linear diffusion on DNA.
Biochemistry - 30 Aug 1994
Jeltsch A, Alves J, Wolfes H, Maass G, Pingoud A
Abstract excerpt
Linear diffusion is a mechanism to accelerate association rates beyond their three-dimensional diffusional limit. It is employed by the restriction endonuclease EcoRI as well as many other proteins interacting with specific DNA sequences to locate their target sites on the macromolecular substrat...
Topics
- Base Sequence
- Binding Sites
- Binding, Competitive
- DNA
- Deoxyribonuclease EcoRI
- Diffusion
- Escherichia coli
- Molecular Sequence Data
- Monte Carlo Method
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- Substrate Specificity