Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme.

PloS one - 1 Jan 2015

Csefalvay Eva, Lapkouski Mikalai, Guzanova Alena, Csefalvay Ladislav, Baikova Tatsiana, Shevelev Igor, Bialevich Vitali, Shamayeva Katsiaryna, Janscak Pavel, Kuta Smatanova Ivana, Panjikar Santosh, Carey Jannette, Weiserova Marie, Ettrich Rüdiger

Abstract excerpt

Type I restriction-modification enzymes are multifunctional heteromeric complexes with DNA cleavage and ATP-dependent DNA translocation activities located on motor subunit HsdR. Functional coupling of DNA cleavage and translocation is a hallmark of the Type I restriction systems that is consistent with their proposed role in horizontal gene transfer. DNA cleavage occurs at nonspecific sites distant from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Cleavage

Share to Escherichia coli Proteins

Share to Exodeoxyribonuclease V

Share to Nucleic Acid Conformation

Share to Protein Sorting Signals

Share to Protein Subunits

Source

Open in PubMed Open full text

Identifiers

PMID: 26039067
DOI: 10.1371/journal.pone.0128700
PMCID: PMC4454674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme.PMID 26039067Read ↗

Interdomain communication in the endonuclease/motor subunit of type I restriction-modification enzyme EcoR124I.Semantic proximity Read ↗

A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I.Semantic proximity Read ↗

Restriction by EcoKI is enhanced by co-operative interactions between target sequences and is dependent on DEAD box motifs.Semantic proximity Read ↗

DNA-mediated coupling of ATPase, translocase and nuclease activities of a Type ISP restriction-modification enzyme.Semantic proximity Read ↗

Structural insights into assembly, operation and inhibition of a type I restriction-modification system.Semantic proximity Read ↗

Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA.Semantic proximity Read ↗

A novel mutant of the type I restriction-modification enzyme EcoR124I is altered at a key stage of the subunit assembly pathway.Semantic proximity Read ↗

Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.Semantic proximity Read ↗

Single-site DNA cleavage by Type III restriction endonuclease requires a site-bound enzyme and a trans-acting enzyme that are ATPase-activated.Semantic proximity Read ↗

Helical interactions in homologous pairing and strand exchange driven by RecA protein.Semantic proximity Read ↗

Coupling DNA-binding and ATP hydrolysis in Escherichia coli RecQ: role of a highly conserved aromatic-rich sequence.Semantic proximity Read ↗

Molecular design and functional organization of the RecA protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.