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Article

Dynamics and thermodynamics of water around EcoRI bound to a minimally mutated DNA chain.

Physical chemistry chemical physics : PCCP - 21 Sept 2012

Ramakrishnan Vigneshwar, Rajagopalan Raj

Abstract excerpt

Water plays an important role in protein-DNA interactions. Here, we examine using molecular dynamics simulations the differences in the dynamic and thermodynamic properties of water in the interfacial and intercalating regions of EcoRI bound to the cognate and to a minimally mutated noncognate DNA chain. The results show that the noncognate complex is not only more hydrated than the cognate complex, but the...

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PMID: 22872098
DOI: 10.1039/c2cp41638g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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