Article
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1993
Ziegler A, Leffell D J, Kunala S, Sharma H W, Gailani M, Simon J A, Halperin A J, Baden H P, Shapiro P E, Bale A E
Abstract excerpt
To identify the sites in the p53 tumor suppressor gene most susceptible to carcinogenic mutation by sunlight, the entire coding region of 27 basal cell carcinomas (BCCs) of the skin was sequenced. Fifty-six percent of tumors contained mutations, and these were UV-like: primarily CC-->TT or C-->T changes at dipyrimidine sites. Such mutations can alter more than half of the 393 amino acids in p53, but two-thirds...
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