Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.

doi:10.1093/carcin/21.11.2113

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Article

Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.

Carcinogenesis - 1 Nov 2000

You Y H, Szabó P E, Pfeifer G P

Abstract excerpt

The most prevalent DNA lesion induced by UV irradiation is the cyclobutane pyrimidine dimer (CPD) which forms at positions of neighboring pyrimidines. In mouse skin tumors induced by irradiation with UVB (280-320 nm) lamps or solar UV simulators, a major mutational hotspot occurs at codon 270 (Arg-->Cys) involving a sequence change from 5'-TCGT to 5'-TTGT. We have shown previously that CPD formation by UVB or...

Topics

Animals
Codon
CpG Islands
DNA Methylation
DNA Repair
Epidermis
Female
Genes, p53
Mice
Mice, Hairless
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Pyrimidine Dimers
Skin Neoplasms
Ultraviolet Rays

Source

Open in PubMed

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PMID: 11062176
DOI: 10.1093/carcin/21.11.2113

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