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Article

Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.

Cancer research - 1 Nov 1997

Tommasi S, Denissenko M F, Pfeifer G P

Abstract excerpt

The most prevalent DNA lesion induced by UV irradiation is the cyclobutane pyrimidine dimer (CPD), which forms at positions of neighboring pyrimidines. Here we show that the rare DNA base 5-methylcytosine is the preferred target for CPD formation when cells are irradiated with natural sunlight. We have mapped the distribution of CPDs formed in normal human keratinocytes along exons of the p53 gene. Codons 196,...

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Source

Identifiers

PMID: 9354431

Genes

CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.PMID 9354431Read ↗

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