Article
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.
Cancer research - 1 Nov 1997
Tommasi S, Denissenko M F, Pfeifer G P
Abstract excerpt
The most prevalent DNA lesion induced by UV irradiation is the cyclobutane pyrimidine dimer (CPD), which forms at positions of neighboring pyrimidines. Here we show that the rare DNA base 5-methylcytosine is the preferred target for CPD formation when cells are irradiated with natural sunlight. W...
Topics
- 5-Methylcytosine
- Codon
- Cytosine
- Genes, p53
- Humans
- Keratinocytes
- Methylation
- Mutation
- Neoplasms, Radiation-Induced
- Pyrimidine Dimers
- Skin Neoplasms
- Sunlight