Analysis of coreceptor versus accessory molecule function of CD8 as a correlate of exogenous peptide concentration.

doi:10.1016/0161-5890(94)90007-8

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Article

Analysis of coreceptor versus accessory molecule function of CD8 as a correlate of exogenous peptide concentration.

Molecular immunology - 1 Aug 1994

Knall C, Ingold A, Potter T A

Abstract excerpt

Substitution in the alpha 3 domain of class I molecules can ablate the recognition of target cells by CD8 dependent cytotoxic T lymphocytes. This effect has been attributed to a destruction of the CD8 alpha binding site on the class I molecule, a hypothesis which is consistent with results obtain...

Topics

Amino Acid Sequence
CD8 Antigens
Cell Line
Fluorescein-5-isothiocyanate
Glycine
H-2 Antigens
Humans
Lysine
Molecular Sequence Data
Mutation
Ovalbumin
Protein Conformation
Receptors, Antigen, T-Cell
Spleen
T-Lymphocytes, Cytotoxic

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