Article
EBV peptide epitope sensitization restores human cytotoxic T cell recognition of Burkitt's lymphoma cells. Evidence for a critical role for ICAM-2.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1993
Khanna R, Burrows S R, Suhrbier A, Jacob C A, Griffin H, Misko I S, Sculley T B, Rowe M, Rickinson A B, Moss D J
Abstract excerpt
The pathogenesis of EBV+ Burkitt's lymphoma (BL) suggests evasion of the CTL response against EBV. Two important features of this tumor have been previously suggested to explain this immune evasion, (a) absence/low expression of cellular adhesion molecules and (b) restricted expression of EBV latent Ag. To determine the relative importance of these features in relation to evasion of EBV-specific CTL, a group of...
Topics
- Amino Acid Sequence
- Antigens, CD
- Antigens, Viral
- Burkitt Lymphoma
- Cell Adhesion Molecules
- Cytotoxicity Tests, Immunologic
- DNA-Binding Proteins
- Epitopes
- Epstein-Barr Virus Nuclear Antigens