Article
Distinct attenuation phenotypes caused by mutations in the translational starting window of Theiler's murine encephalomyelitis virus.
Journal of virology - 1 Apr 1999
Pilipenko E V, Viktorova E G, Khitrina E V, Maslova S V, Jarousse N, Brahic M, Agol V I
Abstract excerpt
Upon initiation of translation of picornavirus RNA, the ribosome is believed to bind the internal ribosome entry site of the template and then to form a productive complex with a downstream RNA segment, the starting window. The presence or absence of an AUG triplet within the starting window of the RNA of Theiler's murine encephalomyelitis virus (a picornavirus) is known to modulate its neurovirulence. In this...
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