Article
Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome.
The Journal of experimental medicine - 1 Sept 1994
Matsushita S, Takahashi K, Motoki M, Komoriya K, Ikagawa S, Nishimura Y
Abstract excerpt
Self-peptides bound to HLA-DR4 (DRA-DRB1*0405 complex) were eluted from the purified DR4 complex, fractionated on reverse-phase HPLC, and subjected to NH2-terminal sequencing. Seven independent sequences were obtained, and all putative peptides synthesized bound to DRB1*0405 as well as DRB1*0406...
Topics
- Alleles
- Amino Acid Sequence
- Autoimmune Diseases
- Binding, Competitive
- Cell Line
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans
- Insulin
- Lymphocyte Activation
- Methimazole
- Molecular Sequence Data