Article
Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression.
Journal of molecular biology - 21 Jul 2000
Combes D, Fedon Y, Grauso M, Toutant J P, Arpagaus M
Abstract excerpt
We report the full coding sequences and the genomic organization of the four genes encoding acetylcholinesterase (AChE) in Caenorhabditis elegans and Caenorhabditis briggsae, in relation to the properties of the encoded enzymes. ace-1 and ace-2, located on chromosome X and I, respectively, encode two AChEs (ACE-1 and ACE-2) that present 35% identity. The C-terminal end of ACE-1 is homologous to the C terminus of...
Topics
- Acetylcholinesterase
- Amino Acid Sequence
- Animals
- Binding Sites
- Caenorhabditis
- Caenorhabditis elegans
- Cholinesterase Inhibitors
- Cloning, Molecular
- Dimerization
- Exons
- Gallamine Triethiodide
- Genes, Helminth
- Inhibitory Concentration 50