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Article

A Family of Acetylcholine-gated Chloride Channel Subunits in Caenorhabditis elegans

4 Dec 2004

Abstract excerpt

The genome of the nematode Caenorhabditis elegans encodes a surprisingly large and diverse superfamily of genes encoding Cys loop ligand-gated ion channels. Here we report the first cloning, expression, and pharmacological characterization of members of a family of anion-selective acetylcholine receptor subunits. Two subunits, ACC-1 and ACC-2, form homomeric channels for which acetylcholine and arecoline, but not...

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PMID: 15579462
DOI: 10.1074/jbc.m412644200

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