Article
A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.
Molecular cell - 19 Jun 2014
Norris Adam D, Gao Shangbang, Norris Megan L, Ray Debashish, Ramani Arun K, Fraser Andrew G, Morris Quaid, Hughes Timothy R, Zhen Mei, Calarco John A
Abstract excerpt
Alternative splicing is important for the development and function of the nervous system, but little is known about the differences in alternative splicing between distinct types of neurons. Furthermore, the factors that control cell-type-specific splicing and the physiological roles of these alternative isoforms are unclear. By monitoring alternative splicing at single-cell resolution in Caenorhabditis elegans,...
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