Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2D6 polymorphism and Parkinson's disease susceptibility.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 1999

Sabbagh N, Brice A, Marez D, Dürr A, Legrand M, Lo Guidice J M, Destée A, Agid Y, Broly F

Abstract excerpt

Following the recent identification of multiple novel mutations and alleles of the cytochrome P450 CYP2D6 gene which cause decreased, increased, or absent enzyme activity, we re-examined the controversial hypothesis of a role of the CYP2D6 polymorphism in Parkinson's disease (PD) susceptibility. For this purpose, a strategy based on PCR-SSCP and RFLP analyses allowing the detection of all known CYP2D6 alleles was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Family Health

Share to France

Share to Gene Dosage

Share to Parkinson Disease

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 10091614
DOI: 10.1002/1531-8257(199903)14:2<230::aid-mds1005>3.0.co;2-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2D6 polymorphism and Parkinson's disease susceptibility.PMID 10091614Read ↗

P450 enzymes and Parkinson's disease: the story so far.Semantic proximity Read ↗

Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease.Semantic proximity Read ↗

CYP2D6 polymorphism in Parkinson's disease: the Rotterdam Study.Semantic proximity Read ↗

Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease.Semantic proximity Read ↗

Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease.Semantic proximity Read ↗

Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.Semantic proximity Read ↗

Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians.Semantic proximity Read ↗

CYP2D6 phenotypes and Parkinson's disease risk: a meta-analysis.Semantic proximity Read ↗

CYP2D6*4 allele polymorphism increases the risk of Parkinson's disease: evidence from meta-analysis.Semantic proximity Read ↗

CYP2D6 polymorphism is not associated with essential tremor.Semantic proximity Read ↗

Genotyping of CYP2D6 in Parkinson's disease.Semantic proximity Read ↗

Mutant debrisoquine hydroxylation genes in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.