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Article

MAP-quest: could we produce constitutively active variants of MAP kinases?

Molecular and cellular endocrinology - 27 Jun 2006

Askari Nadav, Diskin Ron, Avitzour Michal, Yaakov Gilad, Livnah Oded, Engelberg David

Abstract excerpt

Constitutively active mutants that acquired intrinsic activity and escaped regulation, serve as powerful tools for revealing the biochemical, biological and pathological functions of proteins. Such mutants are not available for mitogen-activated protein kinases (MAPKs). It is not known how to mimic the unusual mode of MAPK activation and to enforce, by mutations, their active conformation. In this review we...

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PMID: 16672172
DOI: 10.1016/j.mce.2006.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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