Oncogenic kinase signaling in human neoplasms.

Abstract excerpt

Oncogenic proteins participate in cellular functions that involve transduction of signals from the extracellular environment, through the membrane, into the cytoplasm towards the nucleus, where transcription is initiated to generate proteins that will eventually contribute to the oncogenic phenotype. The wild-type homologues of cellular oncoproteins (proto-oncoproteins) frequently participate in signal...

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