Article
RifR mutations in the beginning of the Escherichia coli rpoB gene.
Molecular & general genetics : MGG - 25 Jul 1994
Severinov K, Soushko M, Goldfarb A, Nikiforov V
Abstract excerpt
In Escherichia coli, mutations conferring rifampicin (Rif) resistance map to the rpoB gene, which encodes the 1342-amino acid beta subunit of RNA polymerase. Almost all sequenced RifR mutations occur within the Rif region, encompassing rpoB codons 500-575. A strong RifR mutation lying outside the...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Codon
- DNA Primers
- Drug Resistance, Microbial
- Escherichia coli
- Genes, Bacterial
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Plasmids