Article
RifR mutations in the beginning of the Escherichia coli rpoB gene.
Molecular & general genetics : MGG - 25 Jul 1994
Severinov K, Soushko M, Goldfarb A, Nikiforov V
Abstract excerpt
In Escherichia coli, mutations conferring rifampicin (Rif) resistance map to the rpoB gene, which encodes the 1342-amino acid beta subunit of RNA polymerase. Almost all sequenced RifR mutations occur within the Rif region, encompassing rpoB codons 500-575. A strong RifR mutation lying outside the Rif region, which changed Val146 to Phe was previously reported, but was not recovered in subsequent studies. Here, we...
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