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Article

Molecular characterization of rpoB mutations conferring cross-resistance to rifamycins on methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Nov 1999

Wichelhaus T A, Schäfer V, Brade V, Böddinghaus B

Abstract excerpt

Mutations of the rpoB gene conferring resistance to rifampin were analyzed in 40 methicillin-resistant Staphylococcus aureus isolates obtained from six countries. Interestingly, the majority of clinical isolates showed multiple mutations within rpoB. The amino acid substitution 481His-->Asn was the most prevalent one, capable of conferring low-level resistance on its own. Cross-resistance to rifampin, rifabutin,...

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Identifiers

PMID: 10543773
DOI: 10.1128/AAC.43.11.2813
PMCID: PMC89569

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