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Article

Molecular determinants of bioactivity of the Saccharomyces cerevisiae lipopeptide mating pheromone.

The Journal of biological chemistry - 5 Aug 1994

Caldwell G A, Wang S H, Xue C B, Jiang Y, Lu H F, Naider F, Becker J M

Abstract excerpt

The a-factor of Saccharomyces cerevisiae (YIIKGVF-WDPAC(Farnesyl)-OCH3) is a peptide pheromone in which post-translational modification with a farnesyl isoprenoid and carboxyl methyl group is required for export and bioactivity. Truncated and carboxyl-terminal modified analogs of the a-factor were synthesized in order to determine the effect of such modifications on bioactivity. Bioactivity studies on...

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PMID: 8051063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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