Article
Transdominant genetic analysis of a growth control pathway.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998
Caponigro G, Abedi M R, Hurlburt A P, Maxfield A, Judd W, Kamb A
Abstract excerpt
Genetic selections that use proteinaceous transdominant inhibitors encoded by DNA libraries to cause mutant phenocopies may facilitate genetic analysis in traditionally nongenetic organisms. We performed a selection for random short peptides and larger protein fragments (collectively termed "perturbagens") that inhibit the yeast pheromone response pathway. Peptide and protein fragment perturbagens that permit...
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