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Article

ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.

DNA repair - 1 Jul 2013

Takagi Masatoshi, Sato Masaki, Piao Jinhua, Miyamoto Satoshi, Isoda Takeshi, Kitagawa Masanobu, Honda Hiroaki, Mizutani Shuki

Abstract excerpt

Chronic myelogenous leukemia (CML) begins with an indolent chronic phase, and subsequently progresses to an accelerated or blastic phase. Although several genes are known to be involved in the progression to blastic phase, molecular mechanisms for the evolution toward blast crisis have not been fully identified. Oncogenic stimuli enforce cell proliferation, which requires DNA replication. Unscheduled DNA...

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Identifiers

PMID: 23694754
DOI: 10.1016/j.dnarep.2013.04.022

Genes

ATM
BCR

Provenance

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