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Article

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1 Sept 1990

Abstract excerpt

The v-abl gene in Abelson virus induces pre-B-cell lymphoma in mice while the BCR/ABL oncogene is associated with chronic myelogenous leukemia and some cases of acute lymphocytic leukemia in humans. Understanding the mechanisms by which these oncogenes affect various cell types has been hampered by a paucity of experimental systems that reproduce the range of biological effects associated with them. We have...

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Identifiers

PMID: 2204061
DOI: 10.1073/pnas.87.17.6649

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