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Article

Debrisoquine oxidation phenotype and susceptibility to lung cancer.

British journal of clinical pharmacology - 1 Jan 1990

Speirs C J, Murray S, Davies D S, Biola Mabadeje A F, Boobis A R

Abstract excerpt

1. It has been suggested that poor metabolisers of debrisoquine are at reduced risk of developing lung cancer from smoking cigarettes. This has been investigated in 82 patients with established cancer of the lung. 2. The frequency of poor metaboliser subjects was not different from that in the normal population. 3. There was no tendency for subjects with lung cancer to metabolise debrisoquine more rapidly than...

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Identifiers

PMID: 2153391
DOI: 10.1111/j.1365-2125.1990.tb03608.x
PMCID: PMC1380067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Debrisoquine oxidation phenotype and susceptibility to lung cancer.PMID 2153391Read ↗

Debrisoquine metabolism and lung cancer risk.Semantic proximity Read ↗

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Metabolic oxidation phenotypes as markers for susceptibility to lung cancer.Semantic proximity Read ↗

Debrisoquin oxidation genotype and susceptibility to lung cancer.Semantic proximity Read ↗

Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.Semantic proximity Read ↗

A protocol for the safe administration of debrisoquine in biochemical epidemiologic research protocols for hospitalized patients.Semantic proximity Read ↗

The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: a meta-analysis.Semantic proximity Read ↗

Lung tumor resection does not affect debrisoquine metabolism.Semantic proximity Read ↗

The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype.Semantic proximity Read ↗

Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.Semantic proximity Read ↗

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