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Article

Efficient nuclear localization of the Ad5 E1A 12S protein is necessary for immortalization but not cotransformation of primary epithelial cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1994

Douglas J L, Quinlan M P

Abstract excerpt

The Ad5 E1A 12S gene encodes a nuclear protein that can immortalize and cooperate with other oncoproteins to transform primary epithelial cells. Expression of the first exon is necessary for the activation of cellular proliferation, immortalization, and transformation. The second exon is necessary for the maintenance of cellular proliferation, immortalization, and the induction of an epithelial cell growth factor...

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PMID: 8049154

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