Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient nuclear localization of the Ad5 E1A 12S protein is necessary for immortalization but not cotransformation of primary epithelial cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1994

Douglas J L, Quinlan M P

Abstract excerpt

The Ad5 E1A 12S gene encodes a nuclear protein that can immortalize and cooperate with other oncoproteins to transform primary epithelial cells. Expression of the first exon is necessary for the activation of cellular proliferation, immortalization, and transformation. The second exon is necessary for the maintenance of cellular proliferation, immortalization, and the induction of an epithelial cell growth factor...

Topics

Adenovirus E1A Proteins
Adenoviruses, Human
Amino Acid Sequence
Arginine
Base Sequence
Cell Division
Cell Nucleus
Cell Transformation, Neoplastic
Cells, Cultured
DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Mutational Analysis

Epithelial Cells

Exons

Genes, ras

Humans

Lysine

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 8049154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8049154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient nuclear localization of the Ad5 E1A 12S protein is necessary for immortalization but not cotransformation of primary epithelial cells.PMID 8049154Read ↗

Immortalization of primary epithelial cells requires first- and second-exon functions of adenovirus type 5 12S.Semantic proximity Read ↗

Modulation of E-cadherin localization in cells expressing wild-type E1A 12S or hypertransforming mutants.Semantic proximity Read ↗

Mutations in CR1 of E1A 12S yield dominant negative suppressors of immortalization and the lytic cycle.Semantic proximity Read ↗

Characterization of a Novel Tripartite Nuclear Localization Sequence in the EGFR FamilySemantic proximity Read ↗

Differences in snRNP localization between transformed and nontransformed cells.Semantic proximity Read ↗

Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells.Semantic proximity Read ↗

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.Semantic proximity Read ↗

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.Semantic proximity Read ↗

Global enhancement of nuclear localization-dependent nuclear transport in transformed cells.Semantic proximity Read ↗

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.Semantic proximity Read ↗

Identification of the nuclear localization signals within the Epstein–Barr virus EBNA-6 proteinSemantic proximity Read ↗

Transcriptional and translational control of ornithine decarboxylase during Ras transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.