Article
Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.
Journal of cell science - 1 Jun 2012
Chung Jeeyun, Khadka Prabhat, Chung In Kwon
Abstract excerpt
Sustained cell proliferation requires telomerase to maintain functional telomeres that are essential for chromosome integrity and protection. Although nuclear import of telomerase transcriptase (hTERT) is required for telomerase activity to elongate telomeres in vivo, the molecular mechanism regulating nuclear localization of hTERT is unclear. We have identified a bipartite nuclear localization signal (NLS; amino...
Topics
- Active Transport, Cell Nucleus
- Amino Acid Sequence
- Cell Line, Transformed
- Cell Nucleus
- Fibroblasts
- Foreskin
- Humans
- Intracellular Space
- Male
- Molecular Sequence Data
- Mutant Proteins
- Mutation
- Nuclear Localization Signals
- Phosphorylation
- Phosphoserine
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-akt
- Reactive Oxygen Species