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Article

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.

Journal of cell science - 1 Jun 2012

Chung Jeeyun, Khadka Prabhat, Chung In Kwon

Abstract excerpt

Sustained cell proliferation requires telomerase to maintain functional telomeres that are essential for chromosome integrity and protection. Although nuclear import of telomerase transcriptase (hTERT) is required for telomerase activity to elongate telomeres in vivo, the molecular mechanism regulating nuclear localization of hTERT is unclear. We have identified a bipartite nuclear localization signal (NLS; amino...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22366458
DOI: 10.1242/jcs.099267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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