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Article

Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells.

Journal of virology - 1 Dec 2003

Tao Mingfang, Kruhlak Michael, Xia Shuhua, Androphy Elliot, Zheng Zhi-Ming

Abstract excerpt

Human papillomavirus (HPV) type 16 E6 (16E6) is an oncogenic, multifunctional nuclear protein that induces p53 degradation and perturbs normal cell cycle control, leading to immortalization and transformation of infected keratinocytes and epithelial cells. Although it is unclear how 16E6 disrupts the epigenetic profile of host genes, its presence in the nucleus is a key feature. The present report describes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14645580
DOI: 10.1128/jvi.77.24.13232-13247.2003
PMCID: PMC296047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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