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Article

Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Oct 1998

Loayza D, Tam A, Schmidt W K, Michaelis S

Abstract excerpt

We are studying the intracellular trafficking of the multispanning membrane protein Ste6p, the a-factor transporter in Saccharomyces cerevisiae and a member of the ATP-binding cassette superfamily of proteins. In the present study, we have used Ste6p as model for studying the process of endoplasmic reticulum (ER) quality control, about which relatively little is known in yeast. We have identified three mutant...

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Identifiers

PMID: 9763443
DOI: 10.1091/mbc.9.10.2767
PMCID: PMC25553

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