Mutations affecting phosphorylation, ubiquitination and turnover of the ABC-transporter Ste6.

doi:10.1016/s0014-5793(02)03621-9

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Article

Mutations affecting phosphorylation, ubiquitination and turnover of the ABC-transporter Ste6.

FEBS letters - 20 Nov 2002

Kölling Ralf

Abstract excerpt

In this report, the role of phosphorylation in the regulation of ubiquitination and turnover of the ABC-transporter Ste6 was investigated. We demonstrate that Ste6 is phosphorylated in vivo and that this phosphorylation is dependent on the presence of an acidic stretch ('A-box') in the linker region previously shown to be important for ubiquitination and fast turnover of Ste6. By mutagenesis, two serine/threonine...

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Topics

ATP-Binding Cassette Transporters
Base Sequence
DNA Primers
Fluorescent Antibody Technique
Fungal Proteins
Glycoproteins
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Phosphorylation

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Serine

Threonine

Ubiquitin

Source

Open in PubMed

Identifiers

PMID: 12435609
DOI: 10.1016/s0014-5793(02)03621-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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