Article
Control of Ste6 recycling by ubiquitination in the early endocytic pathway in yeast.
Molecular biology of the cell - 1 Jun 2005
Krsmanovic Tamara, Pawelec Agnes, Sydor Tobias, Kölling Ralf
Abstract excerpt
We present evidence that ubiquitination controls sorting of the ABC-transporter Ste6 in the early endocytic pathway. The intracellular distribution of Ste6 variants with reduced ubiquitination was examined. In contrast to wild-type Ste6, which was mainly localized to internal structures, these variants accumulated at the cell surface in a polar manner. When endocytic recycling was blocked by Ypt6 inactivation,...
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