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Article

Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway.

Molecules and cells - 30 Apr 1998

Kim S H, Lee S K, Choi K Y

Abstract excerpt

Saccharomyces cerevisiae STE5 is an essential component of the pheromone-mediated-mitogen activated protein kinase (MAPK) pathway. The STE5 protein recruits MAPK module kinases (STE11, STE7, and FUS3) to give a specificity for the pheromone pathway. The STE5 protein contains a putative PEST motif...

Topics

Adaptor Proteins, Signal Transducing
Carrier Proteins
Chromatography, Affinity
Fungal Proteins
Gene Expression
Glutathione Transferase
Intracellular Signaling Peptides and Proteins
MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pheromones

Precipitin Tests

Protein Kinases

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins c-myc

RNA, Messenger

Recombinant Proteins

Source

Identifiers

PMID: 9638643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9638643-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway.PMID 9638643Read ↗

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction.Semantic proximity Read ↗

Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex.Semantic proximity Read ↗

Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.Semantic proximity Read ↗

Saccharomyces cerevisiae Ste5 is important for induction and substrate specificity of Fus3 MAP kinase in the pheromone signaling pathway.Semantic proximity Read ↗

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.Semantic proximity Read ↗

Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p.Semantic proximity Read ↗

Ste50p is involved in regulating filamentous growth in the yeast Saccharomyces cerevisiae and associates with Ste11p.Semantic proximity Read ↗

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in YeastSemantic proximity Read ↗

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.Semantic proximity Read ↗

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.Semantic proximity Read ↗

Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components.Semantic proximity Read ↗

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