The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.

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Article

The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.

Oncogene - 1 May 1994

Matin A, Hung M C

Abstract excerpt

The neu oncogene is frequently overexpressed in breast, ovarian and lung cancers, and its overexpression correlates with poor disease prognosis. The exact mechanism of deregulation of neu expression is not well understood. Our previous studies indicate that the tumor suppressor retinoblastoma gen...

Topics

3T3 Cells
Animals
Base Sequence
Cell Transformation, Neoplastic
Chloramphenicol O-Acetyltransferase
Enhancer Elements, Genetic
ErbB Receptors
Gene Deletion
Genes, Retinoblastoma
Humans
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Proto-Oncogene Proteins

Receptor, ErbB-2

Retinoblastoma Protein

Transcription, Genetic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7908732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7908732-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.PMID 7908732Read ↗

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