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Article

The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.

Oncogene - 1 May 1994

Matin A, Hung M C

Abstract excerpt

The neu oncogene is frequently overexpressed in breast, ovarian and lung cancers, and its overexpression correlates with poor disease prognosis. The exact mechanism of deregulation of neu expression is not well understood. Our previous studies indicate that the tumor suppressor retinoblastoma gene product, Rb, represses transcription of neu through the GTG enhancer (-243 to -234 relative to initiation of...

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PMID: 7908732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence.PMID 7908732Read ↗

Negative regulation of the neu promoter by the SV40 large T antigen.Semantic proximity Read ↗

Transcriptional regulation of neu by RB and E1A in rat-1 cells.Semantic proximity Read ↗

Visualizing dynamic E2F-mediated repression in vivo.Semantic proximity Read ↗

Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.Semantic proximity Read ↗

Regulation of RB Transcription In Vivo by RB Family MembersSemantic proximity Read ↗

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.Semantic proximity Read ↗

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.Semantic proximity Read ↗

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.Semantic proximity Read ↗

A silencer element in the retinoblastoma tumor-suppressor gene.Semantic proximity Read ↗

Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter.Semantic proximity Read ↗

A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein.Semantic proximity Read ↗

Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 retinoblastoma cells in immunodefective mice.Semantic proximity Read ↗

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