Article
A silencer element in the retinoblastoma tumor-suppressor gene.
Oncogene - 1 Jun 1994
Ohtani-Fujita N, Fujita T, Takahashi R, Robbins P D, Dryja T P, Sakai T
Abstract excerpt
We have previously identified two positive regulatory elements in the retinoblastoma gene (RB) promoter. One is an ATF site and the other we have called a retinoblastoma binding factor 1 site. In addition, a consensus E2F site is located directly 3' to the ATF site. Here we demonstrate with gel shift assays that E2F and E2F-dependent complexes can bind in vitro to the E2F site of the RB promoter (RB-E2F site)....
Topics
- Base Sequence
- Binding Sites
- Genes, Regulator
- Genes, Retinoblastoma
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Retinoblastoma Protein
- Tumor Cells, Cultured