Article
Point mutations in the N-<i>ras</i> oncogene in malignant melanoma and congenital naevi
1 Jul 1994
Abstract excerpt
Summary DNA from formalin-fixed and paraffin-processed samples from 100 melanocytic lesions (39 malignant melanomas, 18 cases of dysplastic naevi, and 43 congenital naevi) was extracted, and the sequences around codons 12/13 and 61 of the N-ras oncogene were amplified using the polymerase chain reaction. The amplified product was then analysed both by dot-blotting and by direct sequencing for point mutations. By...
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