Article
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2003
Omholt Katarina, Platz Anton, Kanter Lena, Ringborg Ulrik, Hansson Johan
Abstract excerpt
PURPOSE: Recently, it was reported that BRAF mutations are frequent in melanoma. Previously, we analyzed a large series of paired primary and metastatic melanomas for NRAS codon 61 mutations and showed that they arise early and are preserved during tumor progression. Here, we have screened the same tumor samples for BRAF mutations. EXPERIMENTAL DESIGN: Primary melanomas (n = 71) and corresponding metastases (n =...
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