N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin.

doi:10.1046/j.1523-1747.1998.00376.x

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Article

N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin.

The Journal of investigative dermatology - 1 Nov 1998

Jiveskog S, Ragnarsson-Olding B, Platz A, Ringborg U

Abstract excerpt

Ras mutations, preferentially in codon 61 of the N-ras oncogene, are common in human cutaneous melanomas. In this study, we questioned the association between ras mutations in primary melanomas and sun exposure. DNA was extracted from formalin-fixed primary melanomas: 28 at chronically sun-expose...

Topics

Base Sequence
Genes, ras
Humans
Melanoma
Mucous Membrane
Mutation
Neoplasms, Radiation-Induced
Point Mutation
Polymorphism, Single-Stranded Conformational
Skin Neoplasms
Ultraviolet Rays

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