Article
Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations.
The Journal of investigative dermatology - 1 Jan 2007
Bauer Jürgen, Curtin John A, Pinkel Dan, Bastian Boris C
Abstract excerpt
Most melanocytic nevi develop on sun-exposed skin during childhood and adolescence and commonly harbor BRAF mutations or, less frequently, NRAS mutations. A small subset of nevi is present at birth, and therefore must develop independently of UV light. To assess whether these nevi have a different mutation spectrum than those that develop on sun-exposed skin, we determined the BRAF and NRAS mutation frequencies...
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