Article
Relevance of aromatic residues in transmembrane segments V to VII for binding of peptide and nonpeptide antagonists to the human tachykinin NK(2) receptor.
The Journal of pharmacology and experimental therapeutics - 1 Aug 1999
Renzetti A R, Catalioto R M, Criscuoli M, Cucchi P, Ferrer C, Giolitti A, Guelfi M, Rotondaro L, Warner F J, Maggi C A
Abstract excerpt
We used membranes from Chinese hamster ovary cells stably transfected with the human tachykinin NK(2) receptor, either wild-type or mutated, at four aromatic residues (His(198), Tyr(266), Phe(270), Tyr(289)) located in transmembrane segments V to VII, to assess the role of these residues in the binding of natural tachykinins and peptide and nonpeptide antagonists. Three radioligands, the agonist...
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