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Article

Selective destruction of gliomas in immunocompetent rats by thymidine kinase-defective herpes simplex virus type 1.

Journal of the National Cancer Institute - 17 Aug 1994

Jia W W, McDermott M, Goldie J, Cynader M, Tan J, Tufaro F

Abstract excerpt

BACKGROUND: Thymidine kinase-deficient herpes simplex virus type 1 [tk(-) HSV-1] replicates well in dividing cells but not in nondividing cells such as neurons, suggesting a potential use in the treatment of brain tumors. PURPOSE: We attempted to examine the efficacy of using tk(-) HSV-1 for treating brain tumors in immunocompetent animals. METHODS: 9L glioma cells were cultured and subsequently implanted...

Topics

Animals
Brain Neoplasms
Glioma
Herpesvirus 1, Human
Immunocompetence
Immunohistochemistry
Male
Mutation
Rats
Thymidine Kinase
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8040888
DOI: 10.1093/jnci/86.16.1209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8040888-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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