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Article

Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.

Neurosurgery - 1 Apr 1993

Markert J M, Malick A, Coen D M, Martuza R L

Abstract excerpt

Malignant gliomas are the most common malignant brain tumors and are almost universally fatal. A genetically engineered herpes simplex virus-1 mutant with decreased neurovirulence, dlsptk, has been shown to kill human glioma cells in culture and in animal models. However, intracranial inoculation of dlsptk is limited by fatal encephalitis at higher doses. Therefore, additional engineered and recombinant herpes...

Topics

Acyclovir
Animals
Brain Neoplasms
Encephalitis
Female
Glioma
Herpes Simplex
Humans
Mice
Mice, Nude
Mutation
Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Transplantation, Heterologous

Tumor Cells, Cultured

Source

Identifiers

PMID: 8386343
DOI: 10.1227/00006123-199304000-00016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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