Article
Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant.
Laboratory investigation; a journal of technical methods and pathology - 1 Nov 1995
Kesari S, Randazzo B P, Valyi-Nagy T, Huang Q S, Brown S M, MacLean A R, Lee V M, Trojanowski J Q, Fraser N W
Abstract excerpt
BACKGROUND: Engineered herpes simplex virus (HSV) strains previously have been shown to offer a potential therapeutic alternative to conventional treatment modalities for brain tumors. Because HSV Type 1 strain 1716 has a deletion in the gamma 34.5 neurovirulence gene that renders it avirulent in...
Topics
- Animals
- Brain Neoplasms
- Cell Death
- Female
- Herpesvirus 1, Human
- Humans
- Immunohistochemistry
- Magnetic Resonance Imaging
- Mice
- Mice, Nude
- Microscopy, Electron
- Mutation
- Neoplasm Transplantation
- Survival Rate
- Time Factors
- Tumor Cells, Cultured
- Virus Replication