Article
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Gene therapy - 1 Sept 1994
Boviatsis E J, Scharf J M, Chase M, Harrington K, Kowall N W, Breakefield X O, Chiocca E A
Abstract excerpt
Herpes simplex virus (HSV) mutants or recombinant vectors might be useful oncolytic agents. Three general types of HSV vectors can be potentially used for this purpose: (1) mutants in viral transcription factors, such as ICP0 and ICP4; (2) mutants in enzymes involved in nucleic acid metabolism, such as thymidine kinase (TK) and ribonucleotide reductase (RR); and (3) mutants in neurovirulence factors, such as...
Topics
- Animals
- Brain Neoplasms
- Cell Death
- Disease Models, Animal
- Gene Transfer Techniques
- Genes, Reporter
- Genetic Therapy
- Genetic Vectors
- Gliosarcoma
- Histocytochemistry