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Article

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.

Journal of neuro-oncology - 1 Jan 1994

Kaplitt M G, Tjuvajev J G, Leib D A, Berk J, Pettigrew K D, Posner J B, Pfaff D W, Rabkin S D, Blasberg R G

Abstract excerpt

Herpes simplex virus (HSV) mutants kill dividing tumor cells but spare non-proliferating, healthy brain tissue and may be useful in developing new treatment strategies for malignant brain tumors. Two HSV mutants, a thymidine kinase deficient virus (TK-) and a ribonucleotide reductase mutant (RR-), killed 7/7 human tumor cell lines in tissue culture. The TK-HSV killed Rat RG2 glioma and W256 carcinoma lines but...

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Source

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PMID: 7964989
DOI: 10.1007/BF01306455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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