Article
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.
Journal of neuro-oncology - 1 Jan 1994
Kaplitt M G, Tjuvajev J G, Leib D A, Berk J, Pettigrew K D, Posner J B, Pfaff D W, Rabkin S D, Blasberg R G
Abstract excerpt
Herpes simplex virus (HSV) mutants kill dividing tumor cells but spare non-proliferating, healthy brain tissue and may be useful in developing new treatment strategies for malignant brain tumors. Two HSV mutants, a thymidine kinase deficient virus (TK-) and a ribonucleotide reductase mutant (RR-)...
Topics
- Animals
- Brain
- Brain Neoplasms
- Humans
- Idoxuridine
- Immunocompetence
- Male
- Mutation
- Rats
- Rats, Sprague-Dawley
- Ribonucleotide Reductases
- Simplexvirus
- Tumor Cells, Cultured
- Tyrosine 3-Monooxygenase