Article
Expanded spectrum of viral therapy in the treatment of nervous system tumors.
Journal of neurosurgery - 1 Oct 1992
Markert J M, Coen D M, Malick A, Mineta T, Martuza R L
Abstract excerpt
Despite aggressive therapy, many nervous system neoplasms, including malignant gliomas, medulloblastomas, malignant meningiomas, and neurofibrosarcomas, maintain high mortality rates. The authors recently utilized a thymidine kinase-negative herpes simplex-1 mutant virus, dlsptk, with reduced neurovirulence, for the effective treatment of malignant human gliomas in cell culture and in nude mouse in vivo models....
Topics
- Animals
- Female
- Genetic Engineering
- Glioma
- Humans
- Medulloblastoma
- Meningioma
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mutation
- Neoplasm Transplantation