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Article

Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.

Journal of neurovirology - 1 Feb 1998

Lasner T M, Tal-Singer R, Kesari S, Lee V M, Trojanowski J Q, Fraser N W

Abstract excerpt

HSV-1 mutants in the RL-1 gene encoding the ICP34.5 protein have been demonstrated to have diminished neurovirulence in brain yet replicate as efficiently as parental virus in transformed tissue culture cells. Thus they have been proposed as candidates viruses for human brain tumor therapies. Evaluation of their replicative properties and pathogenesis within the nervous system has been limited. As most patients...

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PMID: 9531017
DOI: 10.3109/13550289809113487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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