Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.

doi:10.3109/13550289809113487

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Article

Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.

Journal of neurovirology - 1 Feb 1998

Lasner T M, Tal-Singer R, Kesari S, Lee V M, Trojanowski J Q, Fraser N W

Abstract excerpt

HSV-1 mutants in the RL-1 gene encoding the ICP34.5 protein have been demonstrated to have diminished neurovirulence in brain yet replicate as efficiently as parental virus in transformed tissue culture cells. Thus they have been proposed as candidates viruses for human brain tumor therapies. Eva...

Topics

Animals
Herpesvirus 1, Human
Humans
Immunochemistry
Immunocompromised Host
Mice
Mice, Nude
Mutation
Neurons
Phenotype
Polymerase Chain Reaction
Virulence

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