Article
Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2000
Herrlinger U, Woiciechowski C, Sena-Esteves M, Aboody K S, Jacobs A H, Rainov N G, Snyder E Y, Breakefield X O
Abstract excerpt
Cellular delivery of a replication-conditional herpes simplex virus type 1 (HSV-1) vector provides a means for gene therapy of invasive tumor cells. LacZ-bearing neural precursor cells, which can migrate and differentiate in the brain, were infected with a ribonucleotide reductase-deficient HSV-1 mutant virus (rRp450) that replicates only in dividing cells. Replication of rRp450 in neural precursor cells was...
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