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Article

Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells.

The journal of gene medicine - 1 Sept 2016

Hossain Jubayer A, Ystaas Lars Rømo, Mrdalj Jelena, Välk Kristjan, Riecken Kristoffer, Fehse Boris, Bjerkvig Rolf, Grønli Janne, Miletic Hrvoje

Abstract excerpt

BACKGROUND: Gene therapeutic strategies with suicide genes are currently investigated in clinical trials for brain tumors. Previously, we have shown that lentiviral vectors delivering the suicide gene HSV-Tk to experimental brain tumors promote a highly significant treatment effect and thus are promising vectors for clinical translation. METHODS: In the present study, we tested lentiviral vectors delivering the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27490042
DOI: 10.1002/jgm.2895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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