Article
Polymorphism in an HLA linked proteasome gene influences phenotypic expression of disease in HLA-B27 positive individuals.
The Journal of rheumatology - 1 Apr 1994
Maksymowych W P, Wessler A, Schmitt-Egenolf M, Suarez-Almazor M, Ritzel G, Von Borstel R C, Pazderka F, Russell A S
Abstract excerpt
OBJECTIVE: To investigate the potential influence of the HLA-linked LMP (low molecular weight polypeptide) genes on disease susceptibility in HLA-B27 individuals with ankylosing spondylitis (AS). METHODS: A polymorphic CfoI restriction enzyme site in the coding region of one proteasome gene was e...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cysteine Endopeptidases
- DNA Primers
- DNA, Complementary
- Female
- Genetic Linkage
- HLA-B27 Antigen
- Homozygote
- Humans
- Iritis
- Male
- Middle Aged
- Molecular Sequence Data
- Multienzyme Complexes