Article
Polymorphism in the LMP2 gene influences disease susceptibility and severity in HLA-B27 associated juvenile rheumatoid arthritis.
The Journal of rheumatology - 1 Apr 1996
Pryhuber K G, Murray K J, Donnelly P, Passo M H, Maksymowych W P, Glass D N, Giannini E H, Colbert R A
Abstract excerpt
OBJECTIVE: To determine the potential contribution of the MHC class II region proteasome subunit gene, LMP2, to disease susceptibility, severity, and phenotype in patients with juvenile rheumatoid arthritis (JRA). METHODS: A CfoI restriction site polymorphism in the coding region of the LMP2 gene...
Topics
- Alleles
- Arthritis, Juvenile
- Base Sequence
- Child
- Child, Preschool
- Cysteine Endopeptidases
- Disease Susceptibility
- Genes, MHC Class II
- Genotype
- HLA-B27 Antigen
- Humans
- Major Histocompatibility Complex
- Molecular Sequence Data
- Oligonucleotide Probes